GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12216499 | 1 | rs4709254 | chr6:159408597 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs12216499 | 1 | rs4709256 | chr6:159409058 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs12216499 | 1 | rs4709258 | chr6:159412010 | RSPH3 | chr6:159398268-159421198:- | 0.29 | 6.05 | 2.96E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs12216499 | 1 | rs4709259 | chr6:159419584 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 5.96 | 4.79E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs943466 | 1 | rs4711346 | chr6:33730996 | LEMD2 | chr6:33738991-33756906:- | 0.24 | 4.85 | 1.68E-6 | Body mass index |
| THCA | cis | rs751728 | 1 | rs4711351 | chr6:33754592 | LEMD2 | chr6:33738991-33756906:- | -0.31 | -7.09 | 4.95E-12 | Crohn's disease |
| THCA | cis | rs471144 | 1 | rs471144 | chr1:152454255 | FLG | chr1:152274651-152297679:- | -0.38 | -3.98 | 8.04E-5 | Inflammatory skin disease |
| THCA | cis | rs2758886 | 1 | rs4711589 | chr6:39230571 | KCNK16 | chr6:39282475-39290330:- | 0.14 | 3.43 | 0.000647 | Cholesterol, total |
| THCA | cis | rs9349407 | 1 | rs4711880 | chr6:47480676 | CD2AP | chr6:47445525-47594994:+ | 0.13 | 3.42 | 0.000676 | Alzheimer's disease (late onset) |
| THCA | cis | rs1474698 | 1 | rs4712120 | chr6:56092916 | COL21A1 | chr6:55921389-56258892:- | 0.75 | 16.06 | 1.01E-46 | Pulse pressure |
| THCA | cis | rs7849270 | 1 | rs4713 | chr9:131910805 | CRAT | chr9:131857075-131873070:- | -0.28 | -6.79 | 3.29E-11 | Blood metabolite ratios |
| THCA | cis | rs1056667 | 1 | rs4713006 | chr6:26519872 | BTN2A3 | chr6:26422317-26431927:+ | 0.19 | 4.52 | 7.82E-6 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713006 | chr6:26519872 | HCG11 | chr6:26521934-26527610:+ | -0.23 | -4.43 | 1.19E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713006 | chr6:26519872 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.05 | 5.86E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4713006 | chr6:26519872 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.77 | 0.00018 | Educational attainment |